在这部无间道3：终极无间剧情/惊悚/犯罪片中,刘建明（刘德华）在陈永仁（梁朝伟）被杀10个月后接受警队内部调查，被架空职权，加上家庭的变故，他的精神状态每况愈下，但他坚信局面很快就会扭转。年轻警司杨锦荣（黎明）在同事看来是怪人一个，他正凭着过人的业绩迈向警队最高层。为了搞清楚杨锦荣的真实身份，刘建明开始对其调查。
刘建明渐渐发现韩琛旧日的生意拍档沈澄（陈道明）与杨锦荣有着千丝万缕的关系，为了置杨锦荣于死地，也为了不让自己的身份曝光，渴望做个好人已久的刘建明开始千辛万苦地找寻一个又一个证据，可是他总在最接近真相时功亏一篑。
Because Chan was being expelled from the school in 1991, SP Yeung Kam Wing graduated, with all police reports distinctions, being the first in whole class. Twelve year later, he was being sent, working to Lau. Ten months after Chan dies, Yeung's spy had blew a case and the spy wish to kill Yeung, but Yeung took his gun and shot him to conclude this failure. Lau gave Yeung car park seat B3A6 when Yeung met Lau. Yeung asked Chan who he is, but Chan didn't remember him. Sam works with Yeung and Lau is recording Yeung's words so that he can sue Yeung. Yeung is a police SP, which is being sent to Sam as the spy from police. Lau doesn't really know Yeung's Police SP position and wish to catch Yeung to the police head. Yeung work with another inspector who is a good friend of Yeung himself. Lau sneaked into Yeung's office, stealing the cassette, and ask the head to tell him that Yeung is the spy of the triad, Sam's triad. The inspector friend of Yeung, without found by Lau, changed Lau's own cassette back to Lau's own player. When Yeung was talking with his staff about the event, Lau brought the head to meet Yeung, and played the tape, because it's changed back with Lau's tape, so Lau ashamed himself instead of able to prove that Yeung is the spy. Lau said why are the police people playing him with this. Yeung, spoke like Chan, Sorry Lau, I am a policeman. Lau said that he is also a police, and shot Yeung's heart. Yeung and the inspector shot Lau back, but Lau succeeded to shoot Yeung's forehead. Yeung was proved deceased with lots of blood. Lau was sent to hospital and met his girl. Sammi told him that her baby is his, and she is able to call Lau as daddy. Ten months ago, when Chan dies, the inspector and Yeung were talking together, Yeung told the inspector that there are still things that need both Yeung and inspector to tackle after Chan die. Inspector cried when he watched Yeung's past. Ten months after, now, Psychologist talked with the inspector after she paid her tribute to Chan, and the inspector paid his tribute to Yeung. Psychologist said that it may be the destiny. Inspector told her that it is chance not destiny. It's always things change human, human can't change things. But Chan, Yeung, Lau had changed some things themselves. Inspector ask Psychologist to let the things to past off, tomorrow still have to face.
浅议终极无间。没人提起的傻强啊。是谁，在敲打我窗？。光荣属于人、胜利属于神。最终读解，天才之作(摘自网络)。空留恨，关于刘建明。别再说沈澄是大陆公安了。二十年后，我才看懂刘建明。我想做个好人。无间道3中，陈慧琳饰演的心理医生的重要性！。
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