在这部高卢勇士之美洲历险喜剧/动画/家庭/历史/冒险片中,罗马帝国时期恺撒的军队横扫欧洲，却对高卢的一个小村庄无能为力。原因是这里的巫师会调制一种让人力大无比的药水。为了打败这个村子恺撒让人绑架了巫师把他送到大洋对岸的地方去。村里的勇士阿斯特里克斯和他的伙伴奥普里克斯一直追到了大洋尽头，这就是美洲大陆。在这里他们和印第安人交上了朋友，成功救回了巫师，并及时回到高卢，拯救了村民。
Caesar has had enough when another legion is hacked to pieces by the damned single indomitable village in Gaul because of the druid's magic potion, so he decides to tackle the problem at the root before conspiratorial senators exploit his humiliation: sycophant Lucullus is ordered to capture the druid (believed immortal) and push him over the edge of the earth (according to the story still believed to be flat as a pizza; actually Greeks and Romans knew better). By pure luck, Lucullus' first net traps both druid and Obelix's pet dog, so the giant and Asterix follow them by ship on the Atlantic, and crash after a storm on the North America coast in pursuit of the druid who was catapulted off the Roman galley before Lucullus triumphantly sets sails back for Europe. They find the druid and meet a tribe of Indians (believing to be in India), literally a whole New World for the equally primitive Celts. At the home front, Caesar sees his chance to overrun the village, but has to wait till the last magic potion has run out, hoping the heroes won't return. In America, the medicine man has a bad eye in the foreigners, especially when the druid proves a dangerous rival...
