在这部地狱男爵动画版：铁血惊魂剧情/动作/科幻/动画/战争/冒险片中,1939年，超自然力量顾问布鲁坦宏教授曾消灭了一个专以残害无辜生命并浴血而得到青春美貌的女吸血鬼娥苏倍安度修，然而此时纽约上城有人想要让这股邪恶的力量重生。教授开始著手调查此事并联合地狱怪客与其他具有超能力的成员展开对抗的计划……
In 1939, young Professor Bruttenholm destroyed Erzsebet Ondrushko, a female vampire who bathed in the blood of innocents to stay young. Now someone in upstate New York is trying to bring her back, and the elderly Professor Broom has decided to investigate it himself. He takes the top BPRD agents, Hellboy, Liz Sherman and Abe Sapien, who are more worried about his welfare than the return of any vampire. Their tune changes when they face a horde of ghosts, a phantom wolf pack, witches, harpies, a giant werewolf and Erzsebet herself. Hellboy ends up battling the Queen of Witches, the goddess Hecate, who wants him to embrace his true destiny, a destiny that includes the destruction of mankind.
