在这部粉红豹与达芬奇喜剧/动画片中,文艺复兴时候的意大利，殿堂级艺术家达芬奇正在他的工作室内创作，而他所用心绘制的作品正是名闻世界的经典画作《蒙娜丽莎》。画作已经接近完成，只需再为这位美人添上朱唇即可。达芬奇一连尝试多种画法，但没有一种令他满意，直到最后他画出了向下撇着的嘴角，似乎这才令他心满意足。画家兴奋地搁下画笔，连忙出门找他的朋友来分享这喜悦的时刻。正在此时，粉红豹刚好路过，他发现蒙娜丽莎的表情如此沮丧犹豫，于是自顾自擦掉那张瘪嘴，添上了一张微笑的嘴。达芬奇的朋友赶来看到画作后非常高兴，真诚地祝贺经典的诞生。可是画家发现作品被篡改后分外恼火，执拗地要表现蒙娜丽莎的忧郁。
就这样，达芬奇和粉红豹围绕蒙娜丽莎展开了一场关乎艺术和尊严的较量……
Another battle of the paintbrush between the Pink Panther and a diminutive painter, who this time is Leonardo Da Vinci, painting his masterpiece, the Mona Lisa. The little Da Vinci paints a pouting mouth on the Mona Lisa, but the Pink Panther decides to covertly replace the pout with a smile. When the smile wins the appreciation of an art patron, Da Vinci is enraged and repaints the pout. The Pink Panther repeatedly changes the pout to a smile while the little painter is not looking, and ultimately it is the Pink Panther's version of the Mona Lisa that hangs in the Louvre.
