在这部动物管理局喜剧/奇幻片中,兽医郝运（陈赫 饰）因为一场猫咪配种事故，意外发现这个世界上有转化者存在。动物管理局带走郝运，但用各种办法都无法洗掉他的记忆，只好迫使他加入动物管理局。从此郝运和战斗力超强的吴爱爱（王子文 饰）组成搭档，开始处理一桩桩动物案件......开启了一个巨大而神秘的都市精灵世界的故事。
Hao Yun, a vet at a private clinic, leads a mundane life until he accidentally discovers the world is inhabited by monsters. Worried about the secret of their existence leaking, monsters capture Hao Yun and attempt to erase his memories. When their attempts fail, Hao Yun is forced to join Monsters Bureau, where he solves cases involving monsters with the help of his new partner, Wu Aiai. As Hao Yun dives deeper into this new world, he learns that even monsters must deal with the mundane struggles of everyday life and the entanglements created by human emotion.
动物世界，比现实社会还现实。。不得不说，这部剧的脑洞太大了！。四星给第四集的鱼精大爷！四爷！浣熊社长！最后两集简直高能，都他妈演技爆表！。总觉得《动物管理局》不会喜剧收场。这部剧究竟是怎样过的审真是一个未解之谜。动物管理局，演员陈赫的口碑之作。真是披荆斩棘了！。这部剧竟然能过审……背后不是有人就是有妖……。来，脑洞一下接下来的十季。被低估的《动物管理局》，看似鬼怪乱神，实则发人深省。
