在这部六号病房惊悚/恐怖片中,教师艾米•罗伯茨（Christine Taylor 克莉斯汀•泰勒 饰）与男朋友尼克（Shane Brolly 申恩•布罗利 饰）相恋多年，但在尼克求婚的当天，一场车祸搅乱了艾米的生活。尼克的汽车和一辆卡车在十字路口相撞，伤者旋即被送往医院。
对医院存有恐惧艾米为了寻找爱人不得不迎着头皮前来寻找，但找遍医院每一个角落，始终未发现尼克的下落。同样遭遇的还有车祸中的卡车司机卢卡斯•戴伦（Jerry O'Connell 饰），他的妹妹也在这所怪异的医院中神秘消失。艾米和卢卡斯结伴通行，却经历了人生中最为恐怖与难忘的一幕……
The school teacher Amy has been proposed by her boyfriend Nick early in the morning and she promises her answer later in the afternoon. After her class, while coming back home, Nick has a car accident in a crossroad with a truck driven by Lucas Dylan. He breaks his leg and an ambulance takes him to the hospital. Amy has a phobia about hospitals, but she gets a taxi and goes to the nearest hospital. However, Nick is not there, and she meets Lucas, who is also looking for his sister that has disappeared in the same weird circumstance. They decide to team up and search together where the victims might have been interned, while Amy experiences the most bizarre and scary situations.
用《Silent Hill》的风格演绎《Stay》的感动。每个人的心底都有一间Room 6 （剧透）。走进死亡。。再多的噩梦也不够。
