在这部嗜血狂魔动作/科幻/恐怖片中,罗马尼亚政府在五年前证实了吸血鬼的存在，为了维护和平，创造和谐共存的局面，政府开发了由康斯坦丁·科瓦克（Roark Critchlow 饰）主持的人与吸血鬼关系部，通过制造出合成血液解决了吸血鬼的饮食问题，从此人类历史翻开新的篇章。在此之后，政府将吸血鬼集中迁往第五区，在这个宛若集中营的封闭所在，罪恶慢慢滋生。某晚，三个吸血鬼和一名人类供血人被残忍杀害，来自美国的警探德里克（Neil Jackson 饰）受命调查此事，他要求科瓦克释放在押的吸血鬼猎人约翰·哈克（Andrew Lee Potts 饰），并协同伦敦的菜鸟警察因尼斯·本奇利（Jonathon Hargreaves 饰）深入调查此事。
吸血狂魔强势袭来，连不死的吸血鬼也面临灭亡的危机……
Bucharest, Romania. The not-too-distant future, but an entirely different city. The human population is dwindling. The vampire population, meanwhile, is exploding. Having emerged from the shadows a decade earlier, vampires now walk openly amongst the human population, as a precarious peace exists between the two. A peace made possible by the introduction of a synthetic blood substitute, dispensed by the Romanian government, making traditional vampire feeding, and preying on humans, no longer necessary. But even so, it's not a peace that everyone is entirely comfortable with...
