在这部青年福尔摩斯悬疑/冒险片中,谢洛克·福尔摩斯12岁时亲眼看见莫里亚蒂教授给自己的父亲注射毒品，长大后决心替父报仇。伦敦发生了一连串案件，作案手法相同，法医华生在每位遇害者的大脑中都检查出了鸦片。福尔摩斯明白幕后主使一定是莫里亚蒂教授，他揭穿了莫假死的秘密，却被其手下绑架。福尔摩斯逃出，带领警察摧毁了以莫里亚蒂为首的贩毒团伙。
The game is afoot. This made for cable movie focuses on the young 20-something Sherlock Holmes. As the movie opens, Sherlock is in pursuit of the evil Moriarty and apparently shoots him to death, but his body cannot be found as he falls in a sewer. Ah, but anyone who knows the Holmes mythos knows that Moriarty is not so easily killed. Nonetheless, Holmes gains notoriety with the press and the police for his apparent killing of the evil Moriarty. This accomplishment brings him into the company of Dr. Watson, an early practitioner of autopsies, for the first time. Together, they start an investigation into the murder of several crimelords and become convinced that Moriarty is alive and behind a plot to organize drug dealing. Given that Moriarty is supposedly dead, Holmes finds it hard to convince Inspector Lestrade. Holmes investigation leads him to a beautiful prostitute, who posed as a rich woman to lure Holmes into the plot.
