在这部会痛的十七岁爱情片中,夏远远（徐娇 饰）是一名十七岁的高中生，因为患有先天性痛觉是绝症，所以性格非常的孤僻和古怪，不爱交际的她成绩在班上也是吊车尾的水平，只有同样融入不到集体中去的二次元男孩罗涛（鲁诺 饰）稍微和她走的近一点。
班上来了一位新的班主任名叫李米（蔡卓妍 饰），她似乎有着和前任大相径庭的教育理念。在李米的坚持之下，夏远远和名为顾明耀（胡夏 饰）的男生成为了同桌，顾明耀品学兼优，是班上无数人眼中的天之骄子，这两个八竿子打不到一起的人走到一起后，会发生那些有趣的故事呢？
Hunan province, southern China, the present day. Senior high-school student Xia Yuanyuan (Jiao Xu), 17, dreams in class about manga characters, her only real interest apart from Taiwan American singer Leehom Wang, whom she's idolised all her life. Her parents divorced when she was young and she's been raised by her paternal grandmother, who indulges her. Always bottom of the class, she has the university entrance exam in three months' time and is constantly berated by her martinet class teacher Gu (Hao Ju). After a row one day with him, she storms out and goes to the beach with biker/hippie friend Luo Tao (Nuo Lu), who is a member of the same manga-cosplay group. They both rail against the conformist world. Following his collapse after Xia Yuanyuan's walkout, Gu is ordered to rest and younger replacement teacher Li Mi (Charlene Choi) takes over. Xia Yuanyuan again walks out when she finds the words \"student trash\" written on her desk. Li Mi finds out what happened from nerdy student Gu Mingyao (Xia Hu), who's known Xia Yuanyuan since primary school and is her only real friend in class. He, however, is under intense pressure from his father to pass the entrance exam and study science and engineering at a good university. Luo Tao takes Xia Yuanyuan to a bar to relax when both of them should be at the cosplay group's rehearsal; fellow member Lisha, who likes Luo Tao, blames everything on Xia Yuanyuan. To bring the competitive class together, Li Mi pairs the students off at desks; Gu Mingyao offers to sit with Xia Yuanyuan and she starts to take more of an interest in studying, which further annoys ambitious class head Lin Wei (Jingzi Shi) who secretly fancies Gu Mingyao. Also jealous of the time that Xu Jiao now spends with Gu Mingyao is Luo Tao, who warns him off. But Gu Mingyao denies he is Xia Yuanyuan's boyfriend, just as Xia Yuanyuan denies she is Luo Tao's girlfriend.
会痛的是投资人那颗小心肝儿。谢谢这部电影让我看到了青春片的底线。会痛的眼睛。承载了太多。我真的以为是围绕那个失痛症写的电影，导演你给我看了个小品？。莫名被拉黑的无奈¬_¬｀。弱智的17岁可能更贴切点。居然没烧死这种十七岁。看不懂的十七岁。我理解的会痛的十七岁。
